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ORIGINAL ARTICLE
Year : 2014  |  Volume : 30  |  Issue : 4  |  Page : 343-346

Insulin-like growth factor alpha changes after tonsillectomy for obstructive and nonobstructive causes


1 Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt
2 Department of Otorhinolaryngology, Banha Teaching Hospital, Benha, Egypt
3 Department of Clinical Pathology, Banha Teaching Hospital, Benha, Egypt
4 Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Correspondence Address:
Mohammad W El-Anwar
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1012-5574.144969

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Objective To assess the effect of tonsillectomy, weather performed for obstructive or nonobstructive causes, on the serum levels of insulin-like growth factor alpha (IGF-1). Patients and methods This prospective study was carried out on 60 children who underwent tonsillectomy or adenotonsillectomy at Zagazig University Hospitals. The children were divided into two groups: the first group included 30 children who underwent tonsillectomy because of obstructive symptoms and the second group included 30 children who underwent tonsillectomy because of recurrent tonsillitis with no manifestations of upper-airway obstruction. Preoperative and 3 months' postoperative blood levels of IGF-1 were estimated and the data were statistically analyzed. Results Six children from the first group (24 children) and four children from the second group (26 children) did not follow-up after surgery and were excluded from the study. Both study groups were matched for age and sex. In the first (obstructive) group, there was a statistically significant increase in the mean level of IGF-1 from 119.08109 ± 27.81797 preoperatively to 222.395 ± 6.62559 postoperatively and the difference was significant (P < 0.0001). However, in the second (infection) group, the mean IGF-1 values increased from 155.0715 ± 89.83015 preoperatively to 191.4075 ± 57.38667 postoperatively, and the difference was not significant (P = 0.0883). Conclusion Insufficient weight and height gain in children who had obstructive adenotonsillar hypertrophy could be attributed to low IGF-1, and this can be corrected after surgery. This is not the case in patients with chronic tonsillitis without upper-airway obstruction, and other factors may explain the retarded growth in these patients. Study design A prospective study.


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