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Year : 2016  |  Volume : 32  |  Issue : 3  |  Page : 141-146

Immunologic changes after diode laser inferior turbinoplasty in allergic rhinitis

1 Otolaryngology Unit, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt
2 Department of Radiobiological Applications, Clinical Pathology Unit, Nuclear Research Center, Atomic Energy Authority, Egypt

Correspondence Address:
Dr. Hazem M.A Saleh
10, El Messaha Square, Apt. 1401, 12311 Giza
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1012-5574.186535

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Objectives It was suggested previously that turbinoplasty by laser improves the symptomatology of allergic rhinitis (AR) not only by a mechanical effect but also by inhibiting the local allergic reaction at the level of the inferior turbinates. The aim of this study was to determine whether the short-term immunologic effects of diode laser, when used to perform inferior turbinoplasty in AR, can also be detected at the systemic level. Patients and methods Twenty patients, seeking a treatment by laser for AR manifestations refractory to local and systemic medical therapy, were included in a prospective study. Blood picture, total immunoglobulin E, interleukin (IL)-4, IL-5, and interferon-γ levels were assessed immediately before and 1 month after diode laser inferior turbinoplasty (DLIT). Results One month after DLIT, the total leukocytic count increased with relative eosinopenia. Total immunoglobulin E and IL-5 decreased, together with insignificant changes in IL-4 and interferon-γ. Conclusion It is not impossible that DLIT modifies the clinical course of AR not only by a mechanical effect but also by its local or even by a systemic immunologic effect. The laser modulation of T-cell functions in the engorged turbinate submucosa is a plausible biomolecular interpretation of the observed effect.

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